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. 2015 Jun 17;26(7):2937–2951. doi: 10.1093/cercor/bhv032

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Figure 6. — Chronic overproduction of p25 stimulates depotentiation and dynamically regulates LTD. (A) Schematic drawing outlines in vitro plasticity experimental design. (B–E) Relative LTP, depotentiation, LTP in SP600125, and LTD in expressing neurons compared with control nonexpressing neurons after 2-day overexpression of p25. Values for the potentiation and depression in control nonexpressing neurons and p25-expressing neurons in LTP (Ctrl: 198.9 ± 4.6%; Exp: 150.9 ± 8.2%; n = 17; P < 0.005 for paired pathways; Ctrl: 95.3 ± 5.4%; Exp: 98.9 ± 4.4%; n = 17; P = 0.55 for control pathways), depotentiation (Ctrl: 109.0 ± 10.7%; Exp: 57.4 ± 6.4%; n = 14; P < 0.05 for paired pathways; Ctrl: 97.4 ± 4.9%; Exp: 93.8 ± 4.4%; n = 14; P = 0.47 for control pathways), LTP in SP600125 (Ctrl: 206.3 ± 10.4%; Exp: 208.3 ± 12.8%; n = 15; P = 0.96 for paired pathways; Ctrl: 89.9 ± 13.0%; Exp: 95.2 ± 3.3%; n = 15; P = 0.46 for control pathways), and LTD (Ctrl: 68.1 ± 4.3%; Exp: 93.6 ± 3.8%; n = 17; P < 0.005 for paired pathways; Ctrl: 97.1 ± 3.9%; Exp: 95.4 ± 4.9%; n = 17; P = 0.88 for control pathways) after 2-day overexpression of p25. (F–J) Relative LTP, depotentiation, LTP in SP600125, and LTD in expressing neurons compared with control nonexpressing neurons after 7-day overexpression of p25. Values for the potentiation and depression in control nonexpressing neurons and p25-expressing neurons in LTP (Ctrl: 195.1 ± 9.0%; Exp: 142.3 ± 5.9%; n = 18; P < 0.005 for paired pathways; Ctrl: 102.9 ± 8.3%; Exp: 100.2 ± 4.3%; n = 18; P = 0.90 for control pathways), depotentiation (Ctrl: 103.8 ± 10.7%; Exp: 54.9 ± 7.9%; n = 14; P < 0.01 for paired pathways; Ctrl: 92.1 ± 4.8%; Exp: 96.0 ± 4.8%; n = 14; P = 0.22 for control pathways), LTP in SP600125 (Ctrl: 205.3 ± 9.0%; Exp: 199.2 ± 8.3%; n = 13; P = 0.55 for paired pathways; Ctrl: 92.3 ± 5.4%; Exp: 95.4 ± 3.5%; n = 13; P = 0.51 for control pathways), LTD (Ctrl: 72.2 ± 5.4%; Exp: 55.8 ± 3.9%; n = 17; P < 0.005 for paired pathways; Ctrl: 100.3 ± 2.9%; Exp: 100.0 ± 3.2%; n = 17; P = 0.91 for control pathways), and LTD with additional SB203580 (Ctrl: 97.0 ± 5.9%; Exp: 92.9 ± 2.9%; n = 16; P = 0.47 for paired pathways; Ctrl: 94.1 ± 3.3%; Exp: 94.5 ± 3.6%; n = 16; P = 0.68 for control pathways) after 7-day overexpression of p25.