Table 1.
Subjects demographics and global brain measures
| ASD (n = 51) | TD controls (n = 48) | |
|---|---|---|
| Age, years | 26 ± 7 (18–43) | 28 ± 6 (18–43) |
| Full-scale IQ (WASI) | 112 ± 13 (77–135) | 115 ± 10 (86–137) |
| ADI total | 35 ± 9 (21–57) | – |
| ADI-R social | 18 ± 5 (9–28) | – |
| ADI-R communication | 14 ± 4 (8–24) | – |
| ADI-R repetitive behaviour | 5 ± 2 (2–10) | – |
| ADOS total | 10 ± 4 (1–21) | – |
| Total surface area (cm2) | 2523 ± 252 | 2494 ± 215 |
| Total white matter volume (cm3) | 488 ± 58 | 499 ± 53 |
| Total gray matter volume (cm3) | 763 ± 86 | 749 ± 72 |
| Total brain volume (cm3) | 1251 ± 136 | 1248 ± 118 |
| Ratio total gray:white matter | 1.568 ± 0.017 | 1.505 ± 0.099* |
Note: Data expressed as mean ± standard deviation (range), surface area expressed as cm2. There were no significant between-group differences in age, FSIQ, or global brain measures at P < 0.05 (2-tailed). *There was a significant between-group difference in the ratio of total GM to total WM (P < 0.05).