Table 1. Susceptibilities of planktonic cells of the 15 Trichosporon asahii isolates against NSAIDs alone and in combination with antifungal agents and the percentage of interpretation effects of each combination (n = 3).
| Drug combination | MIC(range) of drug | FICI | Interpretation | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Alone | In combination | Median | Range | Syn | Ind | Ant | |||
| NSAID(mg/ml) | Antifungal(μg/ml) | NSAID(mg/ml) | Antifungal(μg/ml) | ||||||
| ASA/FLU | 8–16 | 4–32 | 0.125–2 | 0.063–16 | 0.516 | 0.063–1.250 | 7(46.67%) | 8(53.33%) | 0(0.00%) |
| ASA/ITC | 8–16 | 0.125–1 | 0.125–4 | 0.015–0.5 | 0.508 | 0.136–1.008 | 6(40.00%) | 9(60.00%) | 0(0.00%) |
| ASA/VOR | 8–16 | 0.031–0.125 | 0.125–8 | 0.004–0.125 | 0.750 | 0.250–1.125 | 4(26.67%) | 11(73.33%) | 0(0.00%) |
| ASA/AMB | 8–16 | 0.5–4 | 0.125–4 | 0.031–2 | 0.313 | 0.141–0.625 | 12(80.00%) | 3(20.00%) | 0(0.00%) |
| ASA/CAS | 8–16 | 8–32 | 0.25–2 | 2–16 | 0.375 | 0.156–1.125 | 9(60.00%) | 6(40.00%) | 0(0.00%) |
| IBR/FLU | 0.5–2 | 4–32 | 0.031–1 | 0.125–8 | 0.375 | 0.141–1.250 | 10(66.67%) | 5(33.33%) | 0(0.00%) |
| IBR/ITC | 0.5–2 | 0.125–1 | 0.125–0.5 | 0.031–0.5 | 0.500 | 0.188–1.250 | 8(53.33%) | 7(46.67%) | 0(0.00%) |
| IBR/VOR | 0.5–2 | 0.031–0.125 | 0.063–1 | 0.001–0.063 | 0.750 | 0.313–1.250 | 4(26.67%) | 11(73.33%) | 0(0.00%) |
| IBR/AMB | 0.5–2 | 0.5–4 | 0.031–0.5 | 0.063–1 | 0.250 | 0.063–0.750 | 13(86.67%) | 2(13.33%) | 0(0.00%) |
| IBR/CAS | 0.5–2 | 8–32 | 0.016–0.125 | 1–8 | 0.188 | 0.063–1.016 | 11(73.33%) | 4(26.67%) | 0(0.00%) |
| DIC/FLU | 1–4 | 4–32 | 0.031–0.5 | 0.5–16 | 0.516 | 0.070–1.250 | 6(40.00%) | 9(60.00%) | 0(0.00%) |
| DIC/ITC | 1–4 | 0.125–1 | 0.031–2 | 0.031–0.5 | 0.750 | 0.156–2.000 | 4(26.67%) | 11(73.33%) | 0(0.00%) |
| DIC/VOR | 1–4 | 0.031–0.125 | 0.063–2 | 0.001–0.125 | 0.750 | 0.500–1.500 | 2(13.33%) | 13(86.67%) | 0(0.00%) |
| DIC/AMB | 1–4 | 0.5–4 | 0.031–1 | 0.125–1 | 0.313 | 0.094–0.750 | 12(80.00%) | 3(20.00%) | 0(0.00%) |
| DIC/CAS | 1–4 | 8–32 | 0.125–2 | 4–8 | 0.750 | 0.25–1.25 | 5(33.33%) | 10(66.67%) | 0(0.00%) |
MIC, the concentration causing a 50% reduction in optical density of the planktonic cells compared with the optical density of the untreated cells using the same isolates; FICI, fractional inhibitory concentration index, FICI≤0.5, synergy; FICI>0.5–4, indifference; FICI>4, antagonism; Median, the median of the FICIs with one type of combination; Range, the range of the FICIs with one type of combination; Syn, a combination indicating synergistic interaction; Ind, a combination indicating indifferent interaction; Ant, a combination indicating antagonistic interaction; FLU, Fluconazole; ITC, Itraconazole; VOR, Voriconazole, AMB, amphotericin B; CAS, caspofungin; ASA, aspirin; IBR, ibuprofen; DIC, diclofenac sodium