Table 2. Brain regions showing significant differences in BGluM in rats treated with LD MA (4mg/kg) compared with vehicle.
| p < 0.01 Ke > 50 | Brain Region | Cluster Level | Stereotaxic Location of Peak (mm) | |||||
|---|---|---|---|---|---|---|---|---|
| (Ke) | t value | z score | p | x | y | z | ||
| Increased BGluM | primary somatosensory cortex (S1) | 328 | 5.38 | 4.06 | 0 | 6.3 | 3.2 | -2.3 |
| LD MA > veh | insular cortex (Ins) | 177 | 3.76 | 3.16 | 0.001 | -3.9 | 5 | 4.3 |
| ventral posteromedial thalamic nucleus (VPM) | 145 | 3.43 | 2.95 | 0.002 | -3.7 | 5.6 | -3.3 | |
| Decreased BGluM | rhinal cortex (Rhi) | 1039 | 6.19 | 4.42 | 0 | 6.7 | 6.8 | -5.5 |
| LD MA < veh | Striatum / subiculum (CPu/Sub) | 773 | 4.63 | 3.68 | 0 | -5.9 | 6.4 | -4.3 |
| striatum-tail | 4.15 | 3.4 | 0 | -4.9 | 6.6 | -2.7 | ||
| subiculum | 4.07 | 3.36 | 0 | -5.3 | 5.2 | -7.1 | ||
| Cingulate cortex (Cg1) | 108 | 3.84 | 3.21 | 0.001 | 1.0 | 1.0 | 1.3 | |
LD: low dose; MA: methamphetamine; Veh: vehicle (saline); Increased BGluM: Significant clusters (Ke = 50) where metabolic activity was greater in LD MA treated rats compared with vehicle (α = .01); Decreased BGluM: Significant clusters (Ke = 50) where metabolic activity was lower in LD MA treated rats compared with vehicle (α = .01).