Table 3. Brain regions showing significant differences in BGluM in rats treated with HD MA (8mg/kg) compared with vehicle.
| p < 0.01 Ke > 50 | Brain Region | Cluster Level | Stereotaxic Location of Peak (mm) | |||||
|---|---|---|---|---|---|---|---|---|
| (Ke) | t value | z score | p | x | y | z | ||
| Increased BGluM | primary somatosensory cortex (S1) | 251 | 4.14 | 3.39 | 0 | 6.1 | 3 | -2.3 |
| HD MA > Veh | retrosplenial cortex (RSC) | 73 | 3.47 | 2.98 | 0.001 | 1.1 | 1.8 | -8.5 |
| parietal association area (MPtA) | 91 | 2.99 | 2.61 | 0.004 | 1.9 | 8 | -3.3 | |
| Decreased BGluM | rhinal cortex (Rhi) | 694 | 5.26 | 4 | 0 | 6.7 | 6.6 | -5.9 |
| HD MA < Veh | Subiculum / Hippocampus(Sub/Hipp) | 428 | 3.97 | 3.29 | 0 | -5.3 | 5.2 | -7.3 |
| hippocampus | 3.39 | 2.92 | 0.002 | -5.5 | 5.6 | -5.1 | ||
| globus pallidus / striatum tail (GP/CPu) | 92 | 3.72 | 3.14 | 0.001 | -4.7 | 6.8 | -2.5 | |
HD: high dose (8mg/kg); MA methamphetamine; Veh: vehicle (saline); Increased BGluM: Significant clusters (Ke = 50) where metabolic activity was greater in HD MA treated rats compared with vehicle (α = .01); Decreased BGluM: Significant clusters (Ke = 50) where metabolic activity was lower in HD MA treated rats compared with vehicle (α = .01).