Table 4. Brain regions showing significant differences in BGluM in rats treated with LD MA (4mg/kg) compared with HD MA (8 mg/kg).
| p < 0.01 Ke > 50 | Brain Region | Cluster Level | Stereotaxic Location of Peak (mm) | |||||
|---|---|---|---|---|---|---|---|---|
| (Ke) | t value | z score | p | x | y | z | ||
| LD MA> HD MA | temporal association area (TeA) | 65 | 3.71 | 3.13 | 0.001 | -7.3 | 4.2 | -7.1 |
| Paragigantocellular Nucleus (Gn) | 164 | 3.55 | 3.03 | 0.001 | 1.1 | 7.6 | -11.1 | |
| LD MA< HD MA | parietal association / primary somatosensory / retrosplenial cortex | 822 | 4.28 | 3.48 | 0 | 1.7 | 0.6 | -3.3 |
| primary somatosensory cortex (S1) | 3.1 | 2.72 | 0.003 | 2.3 | 0.8 | -0.7 | ||
| retrosplenial cortex (RSC) | 2.87 | 2.55 | 0.005 | -0.5 | 0.6 | -4.1 | ||
LD: low dose (4mg/kg); HD: high dose (8 mg/kg); MA: methamphetamine; LD MA > HD mg/kg MA: Significant clusters (Ke = 50) where metabolic activity was greater in LD MA treated rats compared to HD MA treated rats (α = .01); LD MA < HD mg/kg MA: Significant clusters (Ke = 50) where metabolic activity was lower in LD MA treated rats compared with HD MA treated rats (α = .01).