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. 2016 Jun 8;11(6):e0153289. doi: 10.1371/journal.pone.0153289

Fig 5. TNF-α Stimulated iNOS mRNA and Transcription Factor Expression Dynamics.

Fig 5

The system was simulated with LPS (control), TNF-α, and TNF-α with LPS as inputs. (A-D) show the transcription factors of iNOS under the three stimulatory conditions. STAT1 phosphorylated dimers remain at zero since there is no IFN-γ stimulation. (E) Shows the expression of iNOS under LPS stimulation only. The delay in iNOS expression correlates to LPS causing a delayed activation of iNOS in the absence of other cytokines due to a larger activation cascade. (F) iNOS mRNA gene expression under TNF-α and TNF-α/LPS stimulation respectively.