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. 2016 Jun 8;11(6):e0153289. doi: 10.1371/journal.pone.0153289

Fig 6. IFN-γ Stimulated iNOS mRNA and Transcription Factor Expression Dynamics.

Fig 6

The system was stimulated with IFN-γ, IFN-γ /TNF-α, IFN-γ and LPS, and IFN-γ /TNF-α and LPS as inputs. (A-D) show the transcription factors of iNOS under the four stimulatory conditions. STAT1 phosphorylated dimers are expressed during IFN-γ stimulation (D) and the dynamics are similar to previous models [16]. (E) Shows the expression of TNF-α mRNA under IFN-γ stimulation. IFN-γ by itself is able to activate TNF-α gene expression through IRF1. (F) iNOS mRNA gene expression under the four stimulatory conditions. The magnitude of expression is much greater under IFN-γ stimulation as opposed to TNF-α only activation (Fig 4F), which may be attributed to the activation and compounding effect of TNF-α gene expression in the presence of IFN-γ.