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. Author manuscript; available in PMC: 2016 Oct 6.
Published in final edited form as: Nature. 2016 Apr 6;532(7599):334–339. doi: 10.1038/nature17629

Figure 1. Function and architecture of the human serotonin transporter.

Figure 1

a, Michaelis-Menten plots of serotonin (5-HT) uptake by wild-type (black, circles), ts2 (blue, squares), and ts3 (red, triangles) transporters. Graph depicts an average of three independent experiments, each performed with triplicate measurements (error bars represent s.e.m.). b, Structure of SERT viewed parallel to the membrane. (S)-citalopram molecules (central) and (allosteric) are shown as sticks in dark green and cyan, respectively. Sodium ions are shown as spheres in salmon. Cholesteryl hemisuccinate (CHS) and N-acetylglucosamine (NAG) are shown as sticks. c, View of SERT from the extracellular side of the membrane.