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. Author manuscript; available in PMC: 2016 Oct 6.
Published in final edited form as: Nature. 2016 Apr 6;532(7599):334–339. doi: 10.1038/nature17629

Figure 6. Allosteric modulation of inhibitor binding.

Figure 6

a, The SSRI (S)-citalopram (dark green) binds to the central site by wedging between scaffold helices 3, 8, and 10 and core helices 1 and 6. Sodium and chloride ions are shown as salmon and green spheres. b, (S)-citalopram (cyan) binds to the allosteric site made up of TMs 1b, 6a, 10, 11, EL4, and EL6. Binding to the allosteric site prevents dissociation from the central site.