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. 2016 Jun 8;11(6):e0156127. doi: 10.1371/journal.pone.0156127

Table 2. Clinicopathological variables of patients undergoing liver transplantation for hilar cholangiocarcinoma.

Thirty four patients who underwent an attempt to surgically remove the tumor prior to transplantation and 8 patients with missing variables were excluded.

Variable Patients transplanted for hilar cholangiocarcinoma n = 105 P-value
Group A n = 28 Patients complying with the Mayo Clinic selection criteria for LT, without neo-adjuvant therapy Group B n = 77 Patients not complying with the Mayo Clinic selection criteria.
Mean age in years (± SD) 46 (± 9) 51 (± 10) 0.62
Gender:
Male 18 (64%) 55 (71%) 0.48
Female 10 (36%) 22(39%)
Neo-adjuvant therapy
Yes 0 (0%) 16 (21%) 0.008
No 28 (100%) 59 (79%)
Percutaneous or surgical biopsy prior to LT
Yes 0 (0%) 35 (49%) 0.001
No 28 (100%) 36 (51%)
Adjuvant therapy
Yes 0 (0%) 12 (17%) 0.02
No 28 (100%) 60 (83%)
pT classification
pT1 1 (4%) 6 (8%) 0.51
pT2 13 (48%) 30 (40%)
pT3 13 (48%) 35 (47%)
pT4 0 (0%) 4 (5%)
pN classification
pN0 28 (100%) 34 (46%) 0.001
pN1 0 (0%) 37 (50%)
pN2 0 (0%) 3 (4%)
Distal bile duct margin tumor free
Yes 26 (93%) 66 (89%) 0.58
No 2 (7%) 8 (11%)
PSC
Yes 6 (24%) NA -
No 19 (76%) NA
Median time on waiting list in days* 30 (range: 1–870) NA -
Median preoperative CA19.9 value in kU/L** 48 (range: 4–1410) NA -
90 Day mortality
Yes 3 (11%) 13 (17%) 0.44
No 25 (89%) 64 (83%)

Abbreviations: LT: liver transplantation, PSC: primary sclerosing cholangitis, NA: not available

*Data available for 25 patients.

**Data available for 16 patients.