Table 2. Clinicopathological variables of patients undergoing liver transplantation for hilar cholangiocarcinoma.
Thirty four patients who underwent an attempt to surgically remove the tumor prior to transplantation and 8 patients with missing variables were excluded.
Variable | Patients transplanted for hilar cholangiocarcinoma n = 105 | P-value | |
---|---|---|---|
Group A n = 28 Patients complying with the Mayo Clinic selection criteria for LT, without neo-adjuvant therapy | Group B n = 77 Patients not complying with the Mayo Clinic selection criteria. | ||
Mean age in years (± SD) | 46 (± 9) | 51 (± 10) | 0.62 |
Gender: | |||
Male | 18 (64%) | 55 (71%) | 0.48 |
Female | 10 (36%) | 22(39%) | |
Neo-adjuvant therapy | |||
Yes | 0 (0%) | 16 (21%) | 0.008 |
No | 28 (100%) | 59 (79%) | |
Percutaneous or surgical biopsy prior to LT | |||
Yes | 0 (0%) | 35 (49%) | 0.001 |
No | 28 (100%) | 36 (51%) | |
Adjuvant therapy | |||
Yes | 0 (0%) | 12 (17%) | 0.02 |
No | 28 (100%) | 60 (83%) | |
pT classification | |||
pT1 | 1 (4%) | 6 (8%) | 0.51 |
pT2 | 13 (48%) | 30 (40%) | |
pT3 | 13 (48%) | 35 (47%) | |
pT4 | 0 (0%) | 4 (5%) | |
pN classification | |||
pN0 | 28 (100%) | 34 (46%) | 0.001 |
pN1 | 0 (0%) | 37 (50%) | |
pN2 | 0 (0%) | 3 (4%) | |
Distal bile duct margin tumor free | |||
Yes | 26 (93%) | 66 (89%) | 0.58 |
No | 2 (7%) | 8 (11%) | |
PSC | |||
Yes | 6 (24%) | NA | - |
No | 19 (76%) | NA | |
Median time on waiting list in days* | 30 (range: 1–870) | NA | - |
Median preoperative CA19.9 value in kU/L** | 48 (range: 4–1410) | NA | - |
90 Day mortality | |||
Yes | 3 (11%) | 13 (17%) | 0.44 |
No | 25 (89%) | 64 (83%) |
Abbreviations: LT: liver transplantation, PSC: primary sclerosing cholangitis, NA: not available
*Data available for 25 patients.
**Data available for 16 patients.