Table 3. Association of vitamin D status and relapses (yes/no) during three year follow-up in RRMS-onset patients—Model 2: model 1 plus interaction terms.
| Vitamin D and relapse risk in RRMS-onset population (logistic regression) | ||||
|---|---|---|---|---|
| Parameter | B | Odds Ratio | 95% CI OR | p-value |
| Relapses (ref = no) | ||||
| Baseline 25(OH)D (per 10 nmol/L) deseasonalized | -0.333 | 0.717 | 0.530–0.970 | 0.031 |
| SPMS (ref = RRMS) *Baseline 25(OH)D (per 10 nmol/L) deseasonalized | -0.090 | 0.914 | 0.764–1.094 | 0.327 |
| Age at baseline (years)*Baseline 25(OH)D (per 10 nmol/L) deseasonalized | 0.007 | 1.007 | 1.000–1.0145 | 0.047 |
| SPMS (ref = RRMS) | -0.222 | 0.801 | 0.248–2.592 | 0.712 |
| Age at baseline (years) | -0.077 | 0.926 | 0.884–0.970 | 0.001 |
| Duration of disease (years) | -0.010 | 0.990 | 0.951–1.030 | 0.610 |
| Sex (ref. = female) | -0.217 | 0.805 | 0.516–1.257 | 0.340 |
| EDSS baseline | 0.149 | 1.160 | 1.013–1.329 | 0.032 |
| EDSS baseline2 (centered around mean of 3.8) | -0.093 | 0.911 | 0.868–0.957 | <0.001 |
| Relapse rate 3 years pre-baseline | 0.032 | 1.033 | 0.843–1.265 | 0.757 |
Corrected for “duration of disease (years)*relapse rate 3 years pre-baseline” B 0.029, OR 1.030, p = 0.012
See for characteristics of the RRMS-onset study population S1 Table.