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. Author manuscript; available in PMC: 2017 Jan 19.
Published in final edited form as: Acc Chem Res. 2015 Dec 21;49(1):115–127. doi: 10.1021/acs.accounts.5b00425

Figure 5.

Figure 5

(a) Calculated transition state for the reaction between 2-methylindole and Et(EtO2C)C=Rh2(O2CH)4. (b) Model for indole C–H functionalization suggests that attractive substrate-ligand interaction may contribute to enantioselectivity. (c) Design of a mixed-ligand complex, where the chiral pocket is maintained and tuned by replacing one of the chiral ligands with achiral triphenylacetate.