Table 2.
summary of the 40 cases of mesonephric carcinoma of the cervix reported in the literature, including present case.
| Author | Year | Case | Age | Symptoms | Tumor type | Stage | Treatment | Clinical course | Outcome |
|---|---|---|---|---|---|---|---|---|---|
| McGee | 1962 | 1 | 36 | PC VBV | AC | IB | HRT | Pelvic R (6 yr): NFT | DOD 7 yr |
| Buntine | 1979 | 2 | 48 | ‘fibroids’ | AC | / | HRT + BSO | Vaginal R (7 yr): NFT | DOD 9 yr |
| Valente & Susin | 1987 | 3 | 58 | PMP VBV | AC | IB1 | HRT + BSO + LA | Pelvis, sacral R (2 yr): RT | DOD 2.8 yr |
| Lang | 1990 | 4 | 46 | Cervical polyp | AC | / | HRT | RT | NED 10mo |
| 5 | 55 | / | AC | IB | HRT | / | / | ||
| Ferry & Scully | 1990 | 6 | 55 | Pelvic relaxation | AC | / | HRT + BSO | RT | NED 5 yr |
| Stewart | 1993 | 7 | 37 | Constipation, menorrhagia | AC | I | HRT + BSO + LA | NFT | NED 10 yr |
| Clement | 1995 | 8 | 46 | Menorrhagia, “fibroid uterus” | AC | IB | HRT + BSO + LA | NFT | NED 2 yr |
| 9 | 34 | Menometrorrhagia | AC | IB | HRT + BSO + LA | Abd R (1 yr): CT | NED 2 yr | ||
| 10 | 71 | AC on PAP smear, pelvic mass | AC | IB | HRT + BSO + LA | RT, abd R (4 mo): CT | DOD 8,5mo | ||
| 11 | 67 | PMP VB | AC | IB | HRT + BSO + LA | / | / | ||
| 12 | 37 | PC VB | MMMT | IB | HRT + BSO + LA | Adj CT, abd R (9 & 11 yr): CT | AWD 13 yr | ||
| 13 | 73 | PMP VB | MMMT | IB | HRT + BSO | RT | NED 3 yr | ||
| 14 | 40 | Menorrhagia, cervical polyp | MMMT | IB | HRT + BSO | RT | NED 2.3 yr | ||
| Silver | 2001 | 15 | 62 | PMP VB | AC | IB | HRT + USO | NFT | NED 1.5 yr |
| 16 | 47 | Uterine prolapse | AC | IB | HRT + BSO | NFT | NED 2.1 yr | ||
| 17 | 40 | SIL on PAP smear | AC | IB | HRT + BSO | NFT | NED 3.2 yr | ||
| 18 | 54 | PMP VB | AC | IB | HRT + BSO + LA | NFT | NED 6.1 yr | ||
| 19 | 67 | PMP VB | AC | IB | HRT + BSO | NFT | NED 8.3 yr | ||
| 20 | 72 | AGC on PAP smear | AC | IB | HRT + BSO + LA | RT, rectovaginal R (1.7 yr): CT | NED 2.5 yr | ||
| 21 | 39 | Menorrhagia, cervical “fibroid” | MMMT | IB | HRT + BSO | Mediastinal metastasis (5.6 yr): CT | DOD 6.2 yr | ||
| 22 | 62 | PMP VB | AC | IB | HRT + BSO + LA | NFT | / | ||
| 23 | 56 | Right ovarian cystadenoma | AC | / | HRT + BSO | NFT | NED 7.4 yr | ||
| 24 | 35 | VB, pelvic pain | AC | IIB | RT | Pelvic R (2.2 yr):CT | DOD 3.2 yr | ||
| 25 | 43 | Metrorrhagia, anemia | MMMT | IVB | HRT + BSO + LA + O | CT, bladder & pelvic R (8 mo): RT | DOD 10 mo | ||
| Angeles | 2004 | 26 | 47 | Menometrorrhagia, pelvic pain | AC | IIA | HRT + BSO | RT | NED 1 yr |
| Bagué | 2004 | 27 | 41 | Abnormal VB | AC | IB | HRT + BSO + LA + A | RT | NED 11.4 yr |
| 28 | 24 | / | AC | IIA | / | / | / | ||
| 29 | 45 | PC VB | AC | IB1 | HRT + USO | NFT | NED 3.1 yr | ||
| 30 | 54 | PMP VB | MMMT | IIA | HRT + BSO + LA + O | NFT | DOD 7 mo | ||
| 31 | 62 | / | MMMT | IVB | HRT + BSO | CT & RT, bone R | AWD 3.3 yr | ||
| 32 | 54 | / | MMMT | IB1 | HRT + BSO + LA + O | NFT | NED 1.1 yr | ||
| Yap | 2006 | 33 | 54 | PMP VB | AC | IB1 | HRT + BSO + LA | RT | NED 3.1 yr |
| Fukunaga | 2008 | 34 | 46 | Abnormal VB | AC | IB | HRT + BSO + LA + O | NFT | NED 4 mo |
| Anagnostopoulos | 2012 | 35 | 64 | Suspicious looking cervix | AC | IB1 | HRT + BSO + LA | NFT | NED 6 mo |
| Nomoto | 2012 | 36 | 64 | PMP VB | AC | IB1 | HRT + BSO + LA | Multifocal lung metastases (1 yr): CT | / |
| 37 | 64 | PMP VB | AC | IB1 | HRT + BSO + LA | NFT | / | ||
| Meguro | 2013 | 38 | 63 | PMP VB | MMMT | IIA | HRT + BSO + LA | Local R (7 mo): CRT | NED 7 mo |
| Menon | 2013 | 39 | 65 | PMP VB | AC | IB1 | HRT + BSO + LA | RT | NED 6 mo |
| Present case | 2013 | 40 | 66 | PMP VB | AC | IIB | CRT + HRT + BSO | NFT | NED 2 yr |
PMP VB: postmenopausal vaginal bleeding. PC VB: postcoital vaginal bleeding. HRT: hysterectomy. BSO: bilateral salpingo-oophorectomy. USO: unilateral salpingo-oophorectomy LA: lymphadenectomy. O: omentectomy. A: appendectomy. AC: adenocarcinoma. MMMT: malignant mixed mesonephric tumor. CT: chemotherapy. RT: radiotherapy. CRT: chemo- and radiotherapy. NFT: no further treatment. R: recurrence. Yr: year. Mo: month. NED: no evidence of disease. AWD: alive with disease. DOD: dead of disease.