Table 1.
Comparison of the demographic and motor characteristics of LRRK2 G2385R variant carrier and non- carrier PD patients
| Whole group (n = 301) |
LRRK2 G2385R carriers (n = 76) |
LRRK2 G2385R non-carriers (n = 225) |
P value | |
|---|---|---|---|---|
| Age (years) | 62.68 ± 8.39 | 62.16 ± 8.00 | 62.85 ± 8.53 | 0.533 |
| Age at onset (years) | 56.68 ± 8.89 | 55.57 ± 8.78 | 57.05 ± 8.92 | 0.208 |
| Sex, Male, n (%) | 162 (53.82) | 37 (48.68) | 125 (55.56) | 0.299 |
| Education (years) | 10.23 ± 4.61 | 10.42 ± 4.55 | 10.16 ± 4.63 | 0.689 |
| Disease duration (years) | 5.94 ± 3.74 | 6.57 ± 4.21 | 5.73 ± 3.55 | 0.177 |
| Hoehn & Yahr stage | 2.09 ± 0.81 | 2.15 ± 0.83 | 2.08 ± 0.81 | 0.427 |
| UPDRS-I score | 1.73 ± 1.69 | 1.92 ± 1.98 | 1.67 ± 1.58 | 0.301 |
| UPDRS-II score | 11.28 ± 4.72 | 11.16 ± 5.71 | 11.32 ± 4.35 | 0.992 |
| UPDRS-III score | 26.03 ± 12.51 | 24.55 ± 12.08 | 26.52 ± 12.64 | 0.277 |
| Tremor scores | 6.02 ± 3.85 | 5.24 ± 3.53 | 6.29 ± 3.92 | 0.033* |
| PIGD scores | 4.28 ± 2.62 | 4.88 ± 3.02 | 4.08 ± 2.44 | 0.014* |
| TD phenotype, n (%) | 169 (56.10) | 29 (38.20) | 140 (62.20) | <0.001* |
| PIGD phenotype, n (%) | 112 (37.20) | 43 (56.60) | 69 (30.70) | <0.001* |
| Intermediate, n (%) | 20 (6.60) | 4 (5.30) | 16 (7.10) | 0.498 |
| Motor fluctuations, n (%) | 77 (25.58) | 27 (35.53) | 50 (22.22) | 0.016* |
| Dyskinesias, n (%) | 12 (3.99) | 4 (5.26) | 8 (3.56) | 0.511 |
| LED (mg) | 489.41 ± 299.70 | 553.67 ± 329.84 | 467.71 ± 286.34 | 0.016* |
UPDRS, Unified Parkinson’s Disease Rating Scale; PIGD, postural instability and gait dysfunction dominant; TD, tremor dominant; LED, levodopa equivalent dose