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. Author manuscript; available in PMC: 2017 May 18.
Published in final edited form as: Neuron. 2016 May 18;90(4):724–739. doi: 10.1016/j.neuron.2016.05.003

Figure 5. Trem2 or DAP12 deficiency leads to more severe plaque-associated axonal dystrophy.

Figure 5

(A and B) Visualization of Lamp1-immunolabeled axonal dystrophy (green) around compact (A) and filamentous (B) plaques in AD-like mouse brains. (C–D) Quantification of total dystrophy volume in cortex of AD-like mice with different Trem2 or DAP12 genotypes. N=6 mice for each group of 5XFAD:Trem2 mice; total 2887 plaques analyzed. N=3 mice for each group of APPPS1-21:DAP12 mice; total 1076 plaques analyzed. Student t-tests were used for all statistical comparisons, *: p<0.05, **: p<0.01, ***: p<0.001; a.u.: arbitrary unit. All analyses were performed with somatosensory cortex in mice.