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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Semin Cancer Biol. 2015 Apr 17;35(Suppl):S25–S54. doi: 10.1016/j.semcancer.2015.02.006

Table 3.

Summary of Selected Natural Compounds Active Against Hh Signaling in Cell Proliferation

Compound Effects Cancer Model References
Zerumbone induces apoptosis leukemia, breast cancer [458,459]
Sulforaphane inhibits Shh signaling by blocking Gli transcription, proliferation and induction of apoptosis. pancreatic CSCs [132,245]
Cyclopamine targets Smo protein targeted CSCs in murine medulloblastoma, pancreatic and breast cancers [180,460. 461]
Curcumin 95% inhibition of Gli1 mRNA; 80% down-regulates Gli reporter activity medulloblastoma cells [462]
Apigenin, Baicalein, EGCG, Curcumin, Genistein, Quercetin, Cyclopamine, Resveratrol 95% inhibition of Gli1 mRNA; 80% down-regulates Gli reporter activity prostate cancer cells [463]
EGCG 95% inhibition of Gli1 mRNA; 80% down-regulates Gli reporter activity chondrosarcoma cells [464]