. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Semin Cancer Biol. 2015 Apr 17;35(Suppl):S25–S54. doi: 10.1016/j.semcancer.2015.02.006

Table 5.

Natural Compounds Effective Against Proliferation

Natural product	Targets
Curcumin	NF-κB, PI3K/Akt, and STAT3 [324], mTOR [325]; HIF-1α [476]
Sulforaphane	NF-κB [335], Wnt (β-catenin) [336], Hh [132]
Resveratrol	NF-κB [354], AR [347], IGFR1 [348], Notch-1 [194], Cyclin/CDKs [351], Wnt (β-catenin) [349], STAT3 [357], PI3K/Akt [347], Hh [356]
Genistein	NF-κB [384], FOXO3 [386], Wnt (β-catenin) [392,393], ERβ [397]
EGCG	NF-κB, VEGFR1/R2, EGFR/HER2, PI3K/AKT, IGF/IGF1, MAPK, COX-2 [378]
Brassinin	PI3K/Akt [338]
Indole-3-carbinol	ERα, IGFR1, and IRS-1 [332]
Quercetin	ER [366], HER2 [477], mTOR [478]
Lycopene	NF-κB [479], IGFR1 [480], PI3K/Akt [481], Wnt (β-catenin) and AR [482], cyclins/CDKs [483]