Table 3.
Univariate and multivariate analysis of marital status on CSS in DTC according to sex, age and cancer stage
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Sex | ||||
| Male | ||||
| Married | Reference | Reference | ||
| Widowed | 4.61 (2.71–7.85) | 0.001 | 2.72 (1.59–4.65) | 0.001 |
| Never married | 0.75 (0.50–1.13) | 0.173 | 1.24 (0.81–1.88) | 0.327 |
| Divorced | 1.94 (1.22–3.06) | 0.005 | 1.81 (1.14–2.87) | 0.011 |
| Female | ||||
| Married | Reference | Reference | ||
| Widowed | 7.15 (5.36–9.54) | 0.001 | 2.02 (2.24–4.06) | 0.001 |
| Never married | 0.74 (0.50–1.09) | 0.126 | 1.13 (0.76–1.67) | 0.553 |
| Divorced | 2.22 (1.54–3.18) | 0.001 | 1.73 (1.21–2.49) | 0.003 |
| Age | ||||
| <45 | ||||
| Married | Reference | Reference | ||
| Windowed | 15.96 (2.02–126.00) | 0.001 | 28.12 (3.48–227.25) | 0.002 |
| Never married | 1.90 (0.75–4.78) | 0.174 | 1.46 (0.57–3.74) | 0.436 |
| Divorced | 2.50 (0.54–11.57) | 0.241 | 2.92 (0.62–13.72) | 0.176 |
| ≥45 | ||||
| Married | Reference | Reference | ||
| Widowed | 3.18 (2.49–4.05) | 0.001 | 2.97 (2.30–3.83) | 0.001 |
| Never married | 1.11 (0.82–1.50) | 0.503 | 1.11 (0.82–1.50) | 0.518 |
| Divorced | 1.57 (1.18–2.09) | 0.002 | 1.74 (1.30–2.32) | 0.001 |
| TNM stage | ||||
| Stage I | ||||
| Married | Reference | Reference | ||
| Widowed | 10.82 (5.38–21.74) | 0.001 | 8.44 (4.05–17.59) | 0.001 |
| Never married | 1.22 (0.5802.56) | 0.602 | 1.74 (0.81–3.78) | 0.159 |
| Divorced | 1.95 (0.74–5.11) | 0.178 | 1.87 (0.71–4.95) | 0.208 |
| Stage II | ||||
| Married | Reference | Reference | ||
| Widowed | 2.46 (0.93–6.52) | 0.071 | 3.64 (1.30–10.20) | 0.014 |
| Never married | 1.21 (0.49–3.00) | 0.670 | 1.08 (0.41–2.84) | 0.879 |
| Divorced | 1.32 (0.45–3.85) | 0.610 | 1.64 (0.56–4.82) | 0.366 |
| Stage III | ||||
| Married | Reference | Reference | ||
| Widowed | 2.01 (0.98–4.12) | 0.058 | 2.27 (1.08–4.78) | 0.031 |
| Never married | 0.88 (0.39–1.95) | 0.749 | 0.92 (0.41–2.05) | 0.829 |
| Divorced | 1.20 (0.54–2.66) | 0.665 | 1.23 (0.55–2.76) | 0.613 |
| Stage IV | ||||
| Married | Reference | Reference | ||
| Widowed | 2.73 (2.05–3.65) | 0.001 | 2.63 (1.94–3.57) | 0.001 |
| Never married | 1.13 (0.79–1.62) | 0.501 | 1.07 (0.75–1.54) | 0.710 |
| Divorced | 1.802 (1.29–2.51) | 0.001 | 1.90 (1.35–2.65) | 0.001 |
DTC, differentiated thyroid cancer; CSS, cancer‐specific death. P values refer to comparisons between two groups and were adjusted for age, race, histologic type, surgery procedures, as covariates. NI: not included in the multivariate survival analysis.