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. 2016 Apr 28;36(1):99–107. doi: 10.3892/or.2016.4778

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Copyright: © Han et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Activation of ERK and MAPK contributes to PES-induced apoptosis to a greater extent than suppression of PI3K/Akt signaling. u937 cells were incubated at indicated concentrations of PES with or without the PI3K/Akt (Ly294002) inhibitor, the ERK inhibitor (PD98059), the JNK inhibitor (SP600125), and the p38 inhibitor (SB203580). The results showed that although PES suppressed PI3K/Akt signaling, the activation of ERK contributed more to PES-induced apoptosis rather than PI3K/Akt signaling suppression. (A) 4′,6-Diamidino-2-phenylindole (DAPI) staining, (B) DNA fragmentation test and (C) western blot analysis. The results are from one representative of three independent experiments that showed similar patterns. PES, polyphenols from Korean E. supina; Ly, Ly294002; PD, PD98059; SP, SP600125; SB, SB203580.