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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: J Mol Endocrinol. 2016 Feb 15;56(4):T77–T97. doi: 10.1530/JME-15-0323

Figure 5. General schematic depicting the processing of bovine POMC.

Figure 5

In the anterior lobe, PC1/3 is the primary convertase involved in the generation of 16k N-POMC, ACTH and β-LPH. A more comprehensive processing pattern is seen in the intermediate lobe and hypothalamus yielding α-MSH and β-endorphin. APB, aminopeptidase B-like; AACE, acidic ACTH converting enzyme; CPE, carboxypeptidase E; NAT, N-acetyl transferase; PAM, peptidylglycine α-amidating monooxygenase; -END, -endorphin; JP, joining peptide; -MSH, -melanocyte stimulating hormone; PC, prohormone convertase; Ac, acetyl; K, Lysine; R, Arginine.*β-MSH in humans may not occur naturally (Scott and Lowry 1974).