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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Biomaterials. 2016 May 3;98:53–63. doi: 10.1016/j.biomaterials.2016.04.040

Figure 3. In vivo transfection efficacy of Dg-cSCK in mouse lung.

Figure 3

Mice were dosed intratracheally with a Dg-cSCK complexed with a luciferase expression pDNA (pLuc) at the indicated conditions. Lungs were then subjected to bronchoalveolar lavage (BAL) and tissue was analyzed for luciferase activity and inflammatory cells. (A) Luciferase activity in whole lung adjusted for total protein concentration 2 days after intratracheal delivery of Dg-cSCK:pLuc nanocomplexes (N/P ratio 8:1). Each symbol represents a single animal. (B) Quantification of immune cells in BAL fluid after delivery of pDNA and nanocarriers at indicated days. Data are the mean ± S.D. of 3 to 9 mice for each condition.