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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Bone. 2016 Apr 12;88:39–46. doi: 10.1016/j.bone.2016.04.003

Table 4.

HR-pQCT, ITS, cortical, and mechanical parameters at distal tibia in vertebral fracture subjects and controls

Variables Vertebral Fracture (Mean ± SEM) Control (Mean ± SEM) p-Value OR (95% CI) AUC
HR-pQCT
 vBMD (mg HA/cm3) 201 ± 7 251 ± 6 <0.001c 1.48 (1.13, 1.83) 0.76
 Tb.BMD (mg HA/cm3) 122 ± 5 153 ± 5 <0.001c 1.63 (1.23, 2.03) 0.74
 Ct.BMD (mg HA/cm3) 742 ± 11 792 ± 9 <0.001a 1.35 (1.09, 1.61) 0.68
 BV/TV 0.102 ± 0.004 0.127 ± 0.004 <0.001c 1.77 (1.31, 2.34) 0.74
 Tb.N (1/mm) 1.551 ± 0.046 1.723 ± 0.042 0.007 1.18 (1.02, 1.34) 0.69
 Tb.Th (mm) 0.066 ± 0.002 0.074 ± 0.002 0.001c 1.28 (1.07, 1.49) 0.68
 Tb.Sp (mm) 0.604 ± 0.021 0.523 ± 0.016 0.003 1.41 (1.05, 1.78) 0.69
ITS
 pBV/TV 0.118 ± 0.006 0.148 ± 0.006 <0.001b 1.37 (1.12, 1.62) 0.73
 rBV/TV 0.122 ± 0.005 0.127 ± 0.004 0.19 0.99 (0.96, 1.02) 0.55
 aBV/TV 0.116 ± 0.004 0.140 ± 0.004 <0.001b 1.45 (1.15, 1.74) 0.73
 P-R ratio 1.041 ± 0.073 1.261 ± 0.084 0.02 1.05 (0.97, 1.13) 0.61
 pTb.N(1/mm) 1.356 ± 0.018 1.463 ± 0.016 <0.001c 1.97 (1.26, 2.67) 0.74
 rTb.N(1/mm) 1.702 ± 0.023 1.728 ± 0.021 0.41 0.99 (0.96, 1.03) 0.56
 pTb.Th( mm) 0.231 ± 0.001 0.232 ± 0.001 0.56 0.99 (0.96, 1.01) 0.56
 rTb.Th( mm) 0.212 ± 0.001 0.213 ± 0.001 0.33 1.00 (0.95, 1.04) 0.52
 pTb.S (mm2) 0.198 ± 0.002 0.200 ± 0.002 0.63 0.99 (0.96, 1.02) 0.52
 rTb.l (mm) 0.635 ± 0.004 0.619 ± 0.003 <0.001b 1.41 (1.10, 1.71) 0.70
 P-P Junc.D (1/mm3) 1.742 ± 0.061 2.156 ± 0.065 <0.001c 1.74 (1.28, 2.20) 0.75
 P-R Junc.D (1/mm3) 3.193 ± 0.101 3.766 ± 0.112 <0.001b 1.36 (1.12, 1.59) 0.71
 R-R Junc.D (1/mm3) 2.238 ± 0.117 2.272 ± 0.097 0.82 0.98 (0.97, 0.99) 0.56
Cortical
 Tt.Ar (mm2) 719 ± 19 668 ± 13 0.03a 1.13 (0.96, 1.29) 0.63
 Tb.Ar (mm2) 636 ± 19 577 ± 14 0.01 1.20 (0.98, 1.42) 0.65
 Ct. Ar (mm2) 87 ± 2 98 ± 3 0.006 1.18 (1.02, 1.34) 0.63
 Ct.Th (mm) 0.912 ± 0.029 1.054 ± 0.032 0.001a 1.28 (1.07, 1.50) 0.67
 Ct.Po 0.113 ± 0.005 0.101 ± 0.005 0.07 1.06 (0.97, 1.15) 0.60
 Ct.Po.Dm (mm) 0.180 ± 0.003 0.180 ± 0.002 0.96 0.98 (0.98, 0.98) 0.52
FEA
Whole bone stiffness (N/mm) 199,435 ± 6,533 245,471 ± 7,649 <0.001c 3.44 (2.73, 4.16) 0.74
Trabecular bone stiffness (N/mm) 94,106 ± 5,565 112,027 ± 6,093 0.03 1.46 (1.37, 1.56) 0.61
Whole bone estimated failure load (N) 11,390 ± 292 13,276 ± 368 <0.001b 1.41 (1.04, 1.78) 0.71
Trabecular bone estimated failure load (N) 5,056 ± 267 5,847 ± 274 0.04 1.11 (1.08, 1.20) 0.63
a

p<0.05,

b

p<0.01,

c

p<0.001, group difference remains significant after adjustment for aBMD at total hip.