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. Author manuscript; available in PMC: 2016 Jun 9.
Published in final edited form as: Cell Oncol (Dordr). 2016 Feb 26;39(3):265–277. doi: 10.1007/s13402-016-0272-x

Fig. 1.

Fig. 1

a General structures of series 1 and 2 of cytotoxins containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore. b Synthesis of 3,5-bis(benzylidene)-1-[4-(2-diethylaminoethyloxy) phenylcarbonyl]-4-piperidone hydrochloride hemihydrate, dienone 2a, 1-[4-(2-dimethylaminoethoxy)phenylcarbonyl]-3,5-bis(4-methylbenzylidene)-4-piperidone hydrochloride hemihydrate, dienone 2b and 3,5-bis(benzylidene)-1-[3-(2-dimethylaminoethoxy)phenylcarbonyl]-4-piperidone hydrochloride, dienone 2c. c Structure of curcumin