Table 3.
Immune Responses by Baseline Absolute Lymphocyte Count
| Absolute lymphocyte count <1000 cells/mm3 (N=26) |
Absolute lymphocyte count ≥1000 cells/mm3 (N=28) |
P-value* | |
|---|---|---|---|
| Pre-vaccine GMT (95% CI) | 36.0 (23.7–54.5) | 70.7 (41.5–120.4) | 0.045 |
| Post-vaccine GMT (95% CI) † | 155.3 (100.2–240.6) | 274.9 (183.4–412.2) | 0.066 |
| 9 month GMT (95% CI) † | 58.6 (22.3–154.1) | 249.3 (118.6–524.1) | 0.008 |
| GMR, pre to post | 4.3 | 3.9 | - |
| Inverse GMR, post to 9 months | 2.7 | 1.1 | - |
| Seroconversion (%) | 16 (62) | 19 (68) | 0.777 |
| Seroprotection (%) | 25 (96) | 28 (100) | 0.482 |
| Seroconversion after 1 dose (%) | 4 (15) | 16 (57) | 0.002 |
| Seroprotection after 1 dose (%) | 21 (81) | 26 (93) | 0.243 |
| Seroconversion 9 months vs. post † (%) | 2 (11) | 2 (8) | 1.000 |
| 9 months Seroprotection † (%) | 13 (65) | 22 (88) | 0.083 |
*
Wilcoxon-Mann-Whitney tests for continuous variables, Fisher’s exact tests for categorical variables
†
Missing values were excluded.
GMT, geometric mean titer; GMR, geometric mean ratio; CI, confidence interval