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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 Jan 7;137(6):1863–1871.e6. doi: 10.1016/j.jaci.2015.09.059

FIG 2. IL-6 enhances HuMC degranulation and cytokine production.

FIG 2

(A and B) SA-induced release of β-hexosaminidase from HuMCs cultured in 100 ng/ml SCF and the indicated concentrations of IL-6 (A, n=7; B. n=1). (C–E) GMCSF and IL-8 production by HuMCs cultured in SCF (100 ng/ml) with or without IL-6 (100 ng/ml or as indicated) in response to SA and SCF (10 ng/ml each) (C, n=2; D, n=3; E, n=1). (F) Chemotactic response to 10 ng/ml SCF (n=3). Values are mean ± SEM (A, C, D, and F) or of replicate determinations of one HuMC donor (B and E). *P<0.05, **P<0.01, ***P<0.001.