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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 Jan 7;137(6):1863–1871.e6. doi: 10.1016/j.jaci.2015.09.059

FIG 6. Reversibility of IL-6 effects.

FIG 6

Data indicate days after withdrawal of IL-6 from SCF/IL-6-conditioned HuMC cultures. (A) Degranulation with SA, 10 ng/ml (n=2), (B) methylation of SOCS3 promoter (5′UTR domain, boxed region) in a representative culture or (C) densitometric data from all donors (n=3), and (D–F) expression of SOCS3 (n=5), STAT3 (n=6), and phosphorylated STAT3 (n=7) as indicated by representative immunoblots and densitometric values for all donors. Values are relative mean values ± SEM (day zero equals 100). * P<0.05, **P<0.01, ***P<0.001.