Table 2.

Parameter Estimation under Different Models and Scenarios for Genotyping Family Members of Deceased Cases.

Model	Odds Ratioa	γb	Estimates (S.D.)
			Mixed	Child + Spouse	Child Only
Log-additive for association and co-dominant for survival	log(1) = 0	1	−0.002 (0.120)	−0.004 (0.120)	−0.005 (0.162)
		0.7	−0.002 (0.140)	−0.004 (0.132)	−0.002 (0.175)
		0.5	−0.004 (0.163)	−0.002 (0.146)	−0.009 (0.192)
		0(Naive)		−0.051 (0.130)
	log(1.4) = 0.336	1	0.336 (0.113)	0.334 (0.113)	0.340 (0.147)
		0.7	0.335 (0.131)	0.339 (0.124)	0.335 (0.158)
		0.5	0.333 (0.151)	0.336 (0.136)	0.337 (0.172)
		0(Naive)		0.286 (0.123)
	log(1.8) = 0.588	1	0.588 (0.109)	0.589 (0.109)	0.589 (0.139)
		0.7	0.583 (0.126)	0.588 (0.119)	0.587 (0.149)
		0.5	0.585 (0.144)	0.585 (0.131)	0.583 (0.162)
		0(Naive)		0.539 (0.120)
Dominant for both association and survival	log(1) = 0	1	0.000 (0.143)	0.001 (0.143)	0.001 (0.193)
		0.7	0.004 (0.169)	−0.004 (0.159)	0.002 (0.210)
		0.5	−0.002 (0.197)	−0.003 (0.176)	−0.001 (0.231)
		0(Naive)		−0.046 (0.148)
	log(1.4) = 0.336	1	0.340 (0.143)	0.337 (0.143)	0.336 (0.188)
		0.7	0.336 (0.168)	0.336 (0.158)	0.337 (0.204)
		0.5	0.338 (0.195)	0.337 (0.176)	0.338 (0.224)
		0(Naive)		0.291 (0.144)
	log(1.8) = 0.588	1	0.590 (0.145)	0.590 (0.145)	0.591 (0.187)
		0.7	0.589 (0.170)	0.592 (0.161)	0.589 (0.204)
		0.5	0.592 (0.197)	0.594 (0.179)	0.586 (0.224)
		0(Naive)		0.546 (0.143)

^aThe odds ratio of association.

^bRecruiting probability for family members.

^*Sample size is 500 for cases and 500 for controls; ρ = 0.3, α₀ = −2, and e^α₁ = 1.4 (with survival probabilities 0.62, 0.59 and 0.55 for each genotype.