Table 1.
Experiment parameters. Larger cone images can be found in Supplemental Figure 9.
| Experiment | Center frequency (MHz) | Diameter (in.) | Focusing | Cone | US parameters | N mice |
|---|---|---|---|---|---|---|
| A | 0.5 | 1 | planar |
|
Frequency: 0.3, 0.4, 0.5, and 0.6 MHz Duration: 80 ms CW and 40,000 cycles Intensities: 4 intensities plus sham for each frequency, within a range from 0.1 to 3.5 W/cm2 sppa after attenuation |
5 |
| B | 1.0 | 0.75 | 1.90″ PTF |
|
Frequency: 0.6, 1.0, and 1.4 MHz Duration: 80 ms CW Intensities: 5 intensities plus sham for each frequency, within a range from 0.02 to 9.4 W/cm2 sppa after attenuation |
5 |
| C | 2.25 | 0.75 | 1″ PTF |
|
Frequency: 1.4, 1.9, 2.4, and 2.9 MHz Duration: 80 ms CW Intensities: 4 intensities plus sham for each frequency, within a range from 1.1 to 127 W/cm2 sppa after attenuation |
5 |
| D | 0.5 | 1 | 1.25″ PTF |
|
Frequency: 0.3, 0.4, 0.5, and 0.6 MHz Duration: 80 ms CW Intensities: 4 intensities plus sham for each frequency, within a range from 0.04 to 3.1 W/cm2 sppa after attenuation |
5 |
| E | 2.25 | 0.75 | 1″ PTF |
|
Frequency: 1.4 and 2.9 MHz Duration: 80 ms CW Intensities: at 1.4 MHz, 56.9 W/cm2 sppa after attenuation plus sham; at 2.9 MHz, 90.7 W/cm2 sppa after attenuation plus sham |
6 |
CW = continuous wave; PTF = point target focus; SPPA = spatial peak pulsed average; US = ultrasound.