Figure 5.

Many oligodendroglia in qkv mice retain migratory bipolar morphology. Organotypic cerebellar slice cultures were established from P8 heterozygous control (w/qkv) and quakingviable mutant (qkv/qkv) mice. Images represent maximum-intensity projections and were acquired 1, 5, and 9 days after plating. Individual representative cells in each panel were pseudo-colored to aid visualization of different cell morphologies as follows; green=non-polar, magenta=bi-polar, and cyan=multi-polar. Lower panel shows the percentage of cells with the indicated shapes at each age. Images shown are typical of multiple regions within slices analyzed from at least 3 separate animals per genotype. Scale bar = 100 µm.