Table 1.

Clinicodemographic summary of patients with melanoma of the lower genital tract.

	Patient A	Patient B	Patient C	Patient D
Primary site	Vagina	Vagina	Vagina	Cervix
Age	44	68	61	62
BMI	20.4	23.7	24.4	26
Pathology IHC staining	Melan-A, MITF, HMB-45	MITF, HMB-45	Melan-A, MITF, HMB-45, tyrosinase	Melan-A, HMB-45, S100
Ipilimumab doses	4	4	4	3
Radiation therapy	EBRT 3000 cGy	EBRT 6020 cGy	EBRT 3000 cGy	EBRT 3000 cGy
Post-Ipi/RT imaging	SD	PR	CR	SD
Surgical resection	Vaginectomy	WLE	n/a	Hysterectomy, BSO, vaginectomy
Post-op imaging	CR	CR	CR	CR
Recurrence	No	Yes	No	Yes
Vital status	NED	DOD	NED	AWD

BMI = body mass index, IHC = immunohistochemistry, Melan-A = melanoma antigen, MITF = microphthalmia-associated transcription factor, HMB-45 = human melanoma black 45, EBRT = external beam radiation therapy, Ipi = ipilimumab, SD = stable disease, PR = partial response, CR = complete response, WLE = wide local excision, BSO = bilateral salpingo-oophorectomy, NED = no evidence of disease, DOD = dead of disease, AWD = alive with disease.

All patients had a documented local CR postoperatively.