Table 2.
Selected series of vestibular schwannoma comparing stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT).
| Author | Year | Institution | N. of pts | Median follow-up (months) | Median Dose | Mean/Median volume (cc) | Local control | Hearing preservation | Toxicity |
||
|---|---|---|---|---|---|---|---|---|---|---|---|
| VII n.c. | V n.c. | Others | |||||||||
| SRS vs. FSRT | |||||||||||
| Collen25 | 2011 | Brussels, Belgium | 78 | 56 | SRS 12.5 Gy | 1.7 | 95% | 82% 4 y | 16% | 6% | 5% hydrocephalus |
| 41 | 73 | FSRT 50 Gy, 25 fxs 40–30 Gy, 10 fxs |
6.3 | 59% 4 y | 3% | 3% | |||||
| Kopp24 | 2011 | Munich, Germany | 68 | 30 | SRS 12 Gy | 1.24 | 98.5% | 85% | 4.4% | 13% | NA |
| 47 | 32 | FSRT 54 Gy, 30 fxs | 5.7 | 97.9% | 79% | 2.1% | 4.2% | NA | |||
| Puataweepong26 | 2013 | Bangkok, Thailand | 39 | 61 | SRS 12 Gy | 0.9 | 95% 5 y | 75% 5 y | <1% | 0% | <1% hydrocephalus |
| 79 | 61 | FSRT 25 Gy (range, 18–30), 5 fxs (range, 3–10) |
3.9 | 100% 5 y | 87% 5 y | <1% | 0% | <1% hydrocephalus | |||
| 28 | 45–50 Gy, 20–25 fxs | 9.5 | 95% 5 y | 63% 5 y | |||||||
| Anderson27 | 2014 | Wisconsin, USA | 48 | 83.6 | SRS 12.5 Gy | 0.66 | 97% 5 y 85% 10 y |
60% | 2.1% 5 y | 10.5% 5 y | 2.2% tinnitus |
| 19 | 53.6 | FSRT 45–50.4 Gy, 25–28 fxs |
2.94 | 100% 5 y | 44.4% | 0% | 5.3% | 5.6% vertigo 0% tinnitus |
|||
| 37 | 43.1 | 20 Gy, 5 fxs, once a week | 0.89 | 90.5% 5 y | 63.2% | 2.1% | 20.5% | 2.9% vertigo 2.9% tinnitus |
|||
| Combs28 | 2015 | 3 centres, Germany | 158 | 67 | SRS 13 Gy | 1 | 95% 5 y 94% 10 y |
86% | < 1% | 1.8% | 3% gait uncertainty |
| 291 | 67 | FSRT 57.6 Gy, 32 fxs | 3.5 | 95% 5 y 94% 10 y |
84% | 1% | 14% | ||||
SRS, radiosurgery (marginal dose); FSRT, fractionated stereotactic radiotherapy; y, years; NA, not available.