(a) Chondrosarcomas are composed of cells with varying levels of differentiation toward chondrocytes. For diagnostic purposes, chondroid matrix production is an important feature. Hematoxylin and eosin staining, primary objective magnification 10×. (b) Immuhistochemical evaluation of the expression of the proliferation marker, Ki-67. In this case, focally, up to 10% of cells are positive (meaning that 10% of cells are in a cell cycle phase other than G0). Primary objective magnification 20×.