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(a) Malignant melanomas are typically composed of polygonal cells with high mitotic rates. Multiple mitoses are clearly visible. Hematoxylin and eosin staining, primary objective magnification 40×. (b) Immunohistochemical evaluation of S100 expression, the most consistent marker of melanoma. The tumor cells present strong expression. Primary objective magnification 20×. (c) Immunohistochemical expression of melan-A, a specific marker for melanoma. Primary objective magnification 20×.
