Table 2.
Summary of meta-analysis of association of matrix metalloproteinase-9 gene -1562C>T polymorphism and coronary artery disease in the Chinese population.
| Genetic model | Pooled OR (95% CI) | P-value | Literature number | CAD size | Control size | Pheterogeneity (I2%) |
|---|---|---|---|---|---|---|
| Allelic genetic model | 1.60 (1.25–2.04) | 0.0002* | 10 | 3168 | 2300 | 0.002*(65.1%) |
| Subgroup 1: CT1 < 30 | 1.74 (1.28–2.36) | 0.0004* | 5 | 464 | 453 | 0.38(4.0%) |
| Subgroup 2: CT1≥30 | 1.52 (1.10–2.11) | 0.01* | 5 | 2704 | 1847 | 0.001*(78.3%) |
| Recessive genetic model | 3.05 (1.67–5.56) | 0.0003* | 10 | 3168 | 2300 | 0.50(0%) |
| Dominant genetic model | 2.23 (1.49–3.35) | 0.0001* | 10 | 3168 | 2300 | < 0.00001*(83.5%) |
| Subgroup 1: CC0>90 | 1.73 (1.13–2.65) | 0.01* | 5 | 2709 | 1874 | < 0.0001*(83.6%) |
| Subgroup 2: CC0 < 90 | 3.40 (1.41–8.21) | 0.006* | 5 | 459 | 426 | 0.0003*(80.9%) |
| Homo genetic model | 3.41 (1.87–6.23) | < 0.0001* | 10 | 3168 | 2300 | 0.43(1.1%) |
| Hetero genetic model | 2.03 (1.40–2.93) | 0.0002* | 10 | 3168 | 2300 | < 0.00001*(80.3%) |
| Subgroup 1: T1 < 110 | 3.19 (1.95–5.21) | < 0.00001* | 5 | 443 | 432 | 0.12(45.5%) |
| Subgroup 2: T1>110 | 1.41 (1.00–2.01) | 0.05* | 5 | 2725 | 1868 | 0.003*(75.1%) |
| Additive genetic model | 1.78 (1.33–2.39) | < 0.0001* | 10 | 3168 | 2300 | < 0.0001*(75.9%) |
| Subgroup 1: CT1 < 30 | 1.89 (1.34–2.68) | 0.0003* | 5 | 464 | 453 | 0.26(23.7%) |
| Subgroup 2: CT1≥30 | 1.72 (1.14–2.57) | 0.009* | 5 | 2704 | 1847 | < 0.0001*(85.8%) |
*
P < 0.05.
CAD, coronary artery disease; CI, confidence interval; OR, odds ratio; CAD size, the total number of CAD cases; control size, the total number of control group; homo genetic model, homozygous genetic model; hetero genetic model, heterozygous genetic model; CT1, CT sample size of CAD group; CC0, CC sample size of control group; T1, Total sample size of CAD group.