Table 4.
Distribution of selected virulence and resistance genes among the Staphylococcus aureus isolates.
| Clonal type | n | agr | Cap | Virulence genes | Resistance genes | Others |
|---|---|---|---|---|---|---|
| MRSA CLONAL TYPES: 13 ISOLATES | ||||||
| CC1-MRSA-IV/SCCfus | 2 | III | 8 | hld, hla, hlb*, hlgA, clfA, clfB, lukD, lukF, lukS, lukE, lukX, lukY, entA, entH, entK*, entQ* | blaZ, blaI, blaR, ermC*, Q6GD50, mecA | cna, isaB, sak, scn |
| CC15-MRSA-V/SCCfus | 4 | II | 8 | hld, hlgA, lukF, lukS, lukD, lukE, lukX, lukY, clfA, clfB | blaZ, blaI, blaR, linA*, aacA-aphD, aadD, fosB Q6GD50, mecA | scn, chp, fib, fnB*, isaB* |
| CC80-MRSA-IV PVL+ | 5 | III | 8 | hld, hla, hlgA lukF, lukS, lukD, lukE, lukX, lukY, lukF-PV, lukS-PV, clfA, clfB | blaZ, blaI, blaR, tetK, aphA3, far 1, sat, mecA | sak, scn, etD, edinB, fib |
| CC88-MRSA-IV PVL+ | 2 | III | 8 | hld, hlgA, hla, entA, lukK, lukQ, lukF, lukS, lukD, lukE, lukX, lukY, lukF-PV, lukS-PV, clfA, clfB | blaZ, blaI, blaR, ermC, mecA | sak, chp, scn, isaB |
| MSSA CLONAL TYPES: 12 ISOLATES | ||||||
| CC5-MSSA | 2 | II | 5 | hld, hlgA, hla, entG, entI, entM, entO, entU, lukF, lukS | fosB | sak, scn |
| CC15-MSSA | 1 | II | 8 | hld, hla, lukD, lukE, lukX, lukY | blaZ, blaI, blaR, fosB | chp, scn |
| CC88-MSSA PVL+ | 1 | III | 8 | hld, hlgA, hla, lukF, lukS, lukD, lukE, lukX, lukY, lukS-PV, lukF-PV, clfA, clfB, fib | blaZ, blaI, blaR, fosB, | sak, chp, scn |
| CC101-MSSA | 1 | I | 8 | hld, hlgA, hla, lukF, lukS, lukD, lukE, lukX, lukY, clfA, clfB, fib | fosB | sak, scn |
| CC121-MSSA PVL+ | 1 | IV | 8 | hld, hla, hlgA, entB, entG, entI, entM, entN, entO, entU, lukF-PV, lukS-PV, lukF, entS, entD, entE, entX, entY | blaZ, blaI, blaR, fosB, tetK | sak, scn |
| CC361-MSSA | 2 | I | 8 | hld, hla, entG, entI, entM, entN, entO, entU, lukF, lukS, lukD, lukE, lukX, lukY | blaZ, blaI, blaR, tetK, fosB | sak, scn |
| ST1156-MSSA | 4 | I | 8 | hld, hla, lukF, lukS, lukD, lukE, lukX, lukY, clfA, clfB, | blaZ, blaI, blaR, ermC, fosB | sak, scn, fib |
Key:
implies presence of gene is variable among the isolates, hld, haemolysin delta; hla, haemolysin alpha; hlb, haemolysin beta; hlgA, haemolysin gamma, component A, clfA, clumping factor A; clfB, clumping factor B; lukD, leukocidin D component; lukF, haemolysin gamma/leukocidin, component B; lukS, haemolysin gamma/leukocidin, component C; lukE, leukocidin E component; lukX, leukocidin/haemolysin toxin family protein; lukY, leukocidin/haemolysin toxin family protein; entA, B,G, H, I, K, M, N, O, Q, U, enterotoxin A, B, G, H, I, K, M, N, O, Q, U; lukS-PV, Panton Valentine leukocidin S component; lukF-PV, haemolysin gamma/leukocidin component B; fib, fibrinogen binding protein; blaZ, beta-lactamase; blaI, beta lactamase repressor; blaR, beta-lactamase regulatory protein; fosB, metallothiol transferase; ermC, erythromycin/clindamycin resistance; tetK, tetracycline-resistance; mecA, alternate penicillin binding protein 2, defining MRSA; aacA-aphD, bifunctional enzyme Aac/Aph, gentamicin resistance; aadD, aminoglycoside adenyltransferase, tobramycin resistance; Q6GD50, hypothetical protein associated with fusidic acid resistance; cna, collagen-binding adhesin; isaB, immunodominant antigen B; sak, staphylokinase; scn, Staphylococcal Complement inhibitor; chp, chemotaxis-inhibiting protein (CHIPS); etD, exfoliative toxin D; edinB, epidermal cell differentiation inhibitor B; linA, Lincosamide nucleotidyl transferase; agr, accessory gene regulator; n, number of isolates belonging to the specified clone.