Table 2.

Summary of recent published results (2000–2014) on SRS for GH-secreting pituitary adenomas.

Authors	Patients	Dose (Gy)	Follow-up (months)	Tumor control (%)	Biochemical remission (%)	Late toxicity (%)
						Visual	Hypopituitarism
Zhang et al., 2000	68	31	>12	100	40	NA	NA
Izawa et al., 2000	29	22.5	>6	93	41	0	0
Pollock et al., 2002	26	20	36	100	47	4	16%
Attanasio et al., 2003	30	20	46	100	23	0	6.3%
Jane et al., 2003	64	15	>18	NA	36	0	28
Castinetti et al., 2005	82	26	49.5*	NA	17	1.2	17
Gutt et al., 2005	44	23	22	100	48	NA	NA
Kobayashi et al., 2005	67	18.9	63	100	17	11	15
Jezkova et al., 2006	96	35	53.7	100	44 at 5 years	0	27.1
Voges et al., 2006	64	16.5	54.3	97	14 and 33 at 3 and 5 years	1.4	13 and 18 at 3 and 5 years
Pollock et al., 2007	46	20	63	100	11 and 60 at 2 and 5 years	0	33 at 5 years
Vik-Mo et al., 2007	53	26.5	67	100	58 and 86 at 5 and 10 years	3.8	10 at 5 years
Jagannathan et al., 2008	95	22	57	98	53	4	34
Losa et al., 2008	83	21.5	69	97	52 and 85 at 5 and 10 years	0	10 at 10 years
Ronchi et al., 2009	35	20	114	100	46 at 10 years	0	50
Wan et al., 2009	103	28	67	95	37	0	6
Hayashi et al., 2010	25	25	36	100	40	0	0
Iwai et al., 2010	26	20	84	96	17 and 47 at 5 and 10 years	0	8
Castinetti et al., 2009	43	28	96	100	42.0	0	23
Leenstra et al., 2010	31	20	32	100	NA	NA	45 at 5 years
Erdur et al., 2011	22	23.8	60	95.2	54.5	0	28.6
Sheehan et al., 2011	130	24	31	93.0	53	2.4	24.4
Sicignano et al., 2012	39	25	60	97.7	54	NA	12.3
Franzin et al., 2012	103	22.5	71	97.3	58.3 at 5 years	0	14
Liu et al., 2012	40	21	72	97.5	47.5	0	40
Zeiler et al., 2013	21	14.2	33*	100	30	3.9	13.2
Yan et al., 2013	22	23	98	95	68.2	0	22.7
Wilson et al., 2013	86	20	66	96	18.6	1.2	19.8

NA, not assessed.