Table 3.

Summary of recent published results (2000–2014) on SRS for ACTH-secreting pituitary adenomas.

Authors	Patients	Mean dose (Gy)	Follow-up (months)	Tumor control (%)	Biochemical remission (%)	Late toxicity (%)
						Visual	Hypopituitarism
Izawa et al., 2000	12	23	>6	100	17	NA	0
Sheehan et al., 2000	43	16.5	44	100	63	2.5	16
Hoybye et al., 2001	18	NA	180	100	83	0	66
Kobayashi et al., 2002	20	28.7	60	100	35	NA	NA
Devin et al., 2004	35	14.7	35	91	49	0	40
Castinetti et al., 2007	40	29.5	54	100	42.5	2.5	15
Jagannathan et al., 2007	90	23	45	96	54	5.5a	22
Pollock et al., 2008	8	20	73	100	87 at 4 years	0	26 at 4 years
Tinnel et al., 2008	12	25	37	83.3	50	0	50
Sicignano et al., 2012	15	23.8	60	97.7	64	NA	12.3
Wein et al., 2012	17	18	23	94.1	58.8	0	11.8
Zeiler et al., 2013	8	24.7	35	100	50	3.9	13.2
Grant et al., 2013	15	35	40.2	100	73	3.2	32
Sheehan et al., 2013	96	16	48	98	70	5	36
Wilson et al., 2014	36	20	66	97	25	0	13.9

NA, not assessed.

^aIn 5 patients who underwent reirradiation.