Table 2.

Parameter estimates for cycle probabilities of tolerable AEs, treatment withdrawal and care discontinuation

Parameter description	Estimate	Source
Cycle probability tolerable AE, morphine	0.436	Calculated from [12]a
Cycle probability withdraw because of AE, morphine	0.056	Calculated from [12]b
Cycle probability withdraw because of other reason, morphine	0.013	Calculated from [12]b
Cycle probability tolerable AE, oxycodone	0.464	Calculated from [13]c
Cycle probability withdraw because of AE, oxycodone	0.033	Calculated from [13]d
Cycle probability withdraw because of other reason, oxycodone	0.002	Calculated from [13]d
Cycle probability tolerable AE, novel therapy	0.324	Assumption: proportional reduction of 0.3 relative to oxycodone
Cycle probability withdraw because of AE, novel therapy	0.023	Assumption: proportional reduction of 0.3 relative to oxycodone
Cycle probability withdraw because of other reason, novel therapy	0.002	Assumption: proportional reduction of 0.3 relative to oxycodone
Cycle probability discontinue after failed 1st-line treatment	0.050	Assumption

^aSeven-day probability of nausea/vomiting calculated from 28-day rate plus assumed constant risk of constipation

^bSeven-day probability calculated from midpoint of 28-day probability range

^cAssumed constant risk of experiencing adverse effects from 105-day rate

^dSeven-day probability calculated from 105-day probability