Table 3.

Parameter estimates for model costs

Parameter description	Estimate	Source
Treatment cost per cycle, morphine	£2.63	BNF 67 [22]; NICE [10]
Co-medication cost per cycle, morphine	£2.26	NICE [10]; Curtis et al. [21]
Treatment cost per cycle, oxycodone	£9.20	BNF 67 [22]; Dunlop et al. [17]
Co-medication cost per cycle, oxycodone	£0.04	Dunlop et al. [17]; Curtis et al. [21]
Treatment cost per cycle, novel therapy	£55.21	Assumption: 6 times oxycodone treatment cost
Co-medication cost per cycle, novel therapy	£0.03	Assumption: proportional reduction of 0.3 relative to oxycodone
Adverse event cost per cycle	£6.99	NICE [10]; Curtis et al. [21]
Cost associated with withdrawal	£106.91	NICE [10]; Curtis et al. [21]
Treatment discontinuation cost per cycle	£18.50	Assumption: Half discontinued patients visit GP weekly; Curtis et al. [21]