Table 3.
Performance evaluations of point of care tests for Trichomonas vaginalis from 2010 to 2015.
| Study authors and year | Location | Test used | Sample type | Reference test | Sample size and population | Sensitivity (95% CI) | Specificity (95% CI) | Positive predictive value (95% CI) | Negative predictive value (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| Hegazy et al. 2012 [29] | Mansoura, Dakahlia Governorate, Egypt | OSOM Trichomonas Rapid Test (antigen detection) |
Vaginal swab (care provider-collected) | Positive on either wet mount microscopy or culture | 258 women, age 18–50, attending gynecology and fertility clinic | 98.0% | 99.4% | 99.0% | 98.8% |
|
| |||||||||
| Khatoon et al. 2015 [30] | North India | OSOM Trichomonas Rapid Test (antigen detection) |
Vaginal swab (collector not specified) | Culture | 835 females, age 15–45, at gynecological clinic, symptomatic, excluded pregnant women | 88.2% | 99.6% | 95.2% | 98.9% |
|
| |||||||||
| Nathan et al. 2015 [31] | UK | OSOM Trichomonas Rapid Test (antigen detection) |
Vaginal swab (care provider-collected) | Positive on 2+ of 5 tests: microscopy, culture, OSOM Trichomonas Rapid Test (Sekisui, USA), in-house real time PCR, and Aptima TV assay (Hologic, USA) | 246 women, age 18+, at sexual/reproductive health clinic, symptomatic | 92% (73–99%) | 100% (98.3–100%) | 100% (84–100%) | 99.1% (96.8–99.9%) |
|
| |||||||||
| Khatoon et al. 2015 [30] | North India | Acridine orange staining | Vaginal swab (collector not specified) | Culture | 835 females, age 15–45, at gynecological clinic, symptomatic, excluded pregnant women | 73.5% | 99.6% | 94.3% | 97.7% |
|
| |||||||||
| Khatoon et al. 2015 [30] | North India | Wet mount microscopy | Vaginal swab (collector not specified) | Culture | 835 females, age 15–45, at gynecological clinic, symptomatic, excluded pregnant women | 58.8% | 99.3% | 88.9% | 96.5% |
|
| |||||||||
| Nathan et al. 2015 [31] | UK | Wet mount microscopy | Vaginal swab (care provider-collected) | Positive on 2+ of 5 tests: microscopy, culture, OSOM Trichomonas Rapid Test (Sekisui, USA), in-house real time PCR, and Aptima TV assay (Hologic, USA) | 246 women, age 18+, at sexual/reproductive health clinic, symptomatic | 38% (19–59%) | 100% (98.3–100%) | 100% (66–100%) | 93.7% (89.8–96.4%) |
|
| |||||||||
| Nathan et al. 2015 [31] | UK | Real-time in-house PCR | Vaginal swab (care provider-collected) | Positive on 2+ of 5 tests: microscopy, culture, OSOM Trichomonas Rapid Test (Sekisui, USA), in-house real time PCR, and Aptima TV assay (Hologic, USA) | 246 women, age 18+, at sexual/reproductive health clinic, symptomatic | 88% (68–97%) | 99.6 (97.5–99.99%) |
96% (77–99.2%) | 98.7% (96.1–99.7%) |
|
| |||||||||
| Nathan et al. 2015 [31] | UK | Culture | Vaginal swab (care provider-collected) | Positive on 2+ of 5 tests: microscopy, culture, OSOM Trichomonas Rapid Test (Sekisui, USA), in-house real time PCR, and Aptima TV assay (Hologic, USA) | 246 women, age 18+, at sexual/reproductive health clinic, symptomatic | 88% (68–97%) | 100% (98.3–100%) | 100% (84–100%) | 98.7% (96.2–99.7%) |