Table 1.
Baseline clinical characteristics and placebo-corrected changes in peak VO2
Age (yrs) | Gender | Ethnicity | Hypertension | Diabetes | NYHA Class | BNP | hs-CRP | LVEF | LVEDVi | LVMi | E/E′ | LVEDP | Peak VO2 | VE/VCO2 | OUES | Change in peak VO2 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
#1 | 40 | F | C | Y | N | 2 | 43 | 4.7 | 63 | 33 | 72 | 24 | n/a | 16.9 | 24.6 | 2.08 | +1.9 |
#2 | 52 | F | AA | Y | N | 2 | 8 | 9.9 | 63 | 43 | 131 | 8 | n/a | 20.5 | 23.2 | 2.21 | −1.1 |
#3 | 55 | F | AA | Y | Y | 3 | 39 | 3.5 | 57 | 59 | 123 | 11 | 18 | 16.2 | 30.6 | 1.79 | +1.7 |
#4 | 55 | F | AA | Y | N | 2 | 19 | 6.6 | 58 | 33 | 91 | 11 | n/a | 18.7 | 22.3 | 2.85 | −1.0 |
#5 | 57 | F | AA | Y | Y | 2 | 2 | 17.0 | 57 | 41 | 79 | 11 | 17 | 14.1 | 25.2 | 2.12 | +3.0 |
#6 | 60 | F | AA | Y | Y | 3 | 25 | 11.5 | 60 | 62 | 125 | 15 | n/a | 13.8 | 24.9 | 1.92 | −0.7 |
#7 | 62 | F | C | Y | Y | 3 | 39 | 5.0 | 64 | 37 | 68 | 11 | 34 | 16.1 | 29.6 | 2.54 | +2.1 |
#8 | 63 | F | AA | Y | N | 2 | 11 | 15.2 | 74 | 34 | 89 | 21 | 20 | 14.4 | 22.2 | 1.8 | +0.4 |
#9 | 64 | F | C | Y | Y | 3 | 112 | 2.6 | 53 | 40 | 78 | 10 | n/a | 13.1 | 33 | 1.34 | +1.7 |
#10 | 64 | F | AA | Y | Y | 3 | 131 | 15.5 | 67 | 41 | 90 | 20 | n/a | 11.4 | 21.1 | 2.02 | +3.5 |
#11 | 65 | M | C | Y | Y | 2 | 23 | 3.1 | 59 | 60 | 68 | 11 | n/a | 17.3 | 31.1 | 1.73 | +3.0 |
#12 | 70 | F | AA | Y | N | 3 | 414 | 18.2 | 51 | 78 | 100 | 19 | 15 | 9.4 | 45.4 | 1.22 | +1.8 |
Abbreviations: AA=African-American; BNP=Brain natriuretic peptide (pg/ml) ; C=Caucasian; E/E′= ratio of transmitral Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity; F=female; hs-CRP=high sensitivity C-reactive protein (mg/l); LVEDVi=left ventricular end-diastolic volumeindex (ml/m2); LVEF=left ventricular ejection fraction (%); LV Mass index=left ventricular mass index (g/m2); M=male; N=no; n/a=not available; NYHA Class=New York Heart Association functional classification system for heart failure; OUES= Oxygen-uptake efficiency slope; Peak VO2=maximal oxygen consumption during cardiopulmonary exercise testing (ml•kg−1•min−1); VE/VCO2=ventilatory equivalent ratio for carbon dioxide; Y=yes.