Table 1.
Patient details
| Case No. | Demographics |
l-DOPA equiv. | Ketamine infusion | Clinical effects of ketamine | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| age | sex | disease duration | Hoehn and Yahr | indication | starting dose | max. dose | duration, h | average dose | Effect on dyskinesia |
Pain |
side effects RASS | |||||
| before | after | before | during | after | ||||||||||||
| 1 | 64 | m | 20 | 3 | 2,400 | back pain | 0.05 | 0.3 | 50 | n.d. | +++ | + | n.d. | n.d. | n.d. | n.d. |
| 2 | 62 | m | >10 | 3 | 2,150 | painful dyskinesia | 0.15 | 0.15 | 72 | 0.15 | +++ | + | n.d. | n.d. | n.d. | n.d. |
| 3 | 84 | m | 12 | 3 | 1,971 | back pain | 0.05 | 0.15 | 65 | 0.09 | + | none | 5 | 0.73 | 0 | 0.14 |
| 4 | 46 | f | 6 | 2.5 | 400 | headache | 0.05 | 0.15 | 96 | 0.09 | none | none | 10 | 5.5 | 5 | 0.42 |
| 5 | 54 | f | 8 | 2.5 | 400 | headache | 0.05 | 0.15 | 72 | 0.12 | none | none | n.d. | n.d. | n.d. | n.d. |
n.d. = Not determined; UPDRS = Unified Parkinson's Disease Rating Scale, 0–10 Pain Scale Assessment; RASS = Richmond Agitation Sedation Scale.