Table 2.
Factors associated with changes in HAI (∆HAI) and WBAI (∆WBAI) during the 3-year follow-up
| Univariate analysis |
Multivariate analysis |
|||
|---|---|---|---|---|
| correlation coefficient | p value | standardized β coefficient (SE) | p value | |
| ∆HAI | r2 = 0.388, p < 0.001 | |||
| ∆eGFR (ml/min/1.73 m2) | −0.396 | 0.002 | −0.282 (0.007) | 0.022 |
| Age (years) | 0.377 | 0.003 | 0.213 (0.012) | 0.074 |
| DBP at base (mm Hg) | −0.297 | 0.020 | −0.096 (0.007) | 0.425 |
| ∆HDL-cholesterol (mg/dl) | −0.288 | 0.025 | −0.151 (0.007) | 0.461 |
| ApoE ε4 carrier | 0.277 | 0.031 | 0.285 (0.178) | 0.013 |
| Albuminuria during follow-up | 0.267 | 0.037 | 0.232 (0.120) | 0.038 |
| ∆WBAI | r2 = 0.295, p = 0.008 | |||
| ∆PWML grade | 0.306 | 0.016 | 0.196 (0.728) | 0.123 |
| Waist circumference at base (cm) | 0.299 | 0.020 | 0.214 (0.022) | 0.145 |
| Duration of diabetes (years) | 0.276 | 0.031 | 0.173 (0.027) | 0.223 |
| Treatment modality | 0.276 | 0.031 | 0.063 (0.445) | 0.694 |
| Retinopathy | 0.272 | 0.034 | 0.082 (0.307) | 0.578 |
| log CRP at base | 0.253 | 0.049 | 0.036 (0.403) | 0.797 |
| ∆SBI (number of infarcts) | 0.253 | 0.049 | 0.266 (0.697) | 0.031 |
Variables with p < 0.05 in univariate analysis were entered into the multiple regression analysis. Retinopathy: 0 = none; 1 = simple; 2 = proliferative. Treatment modality: 0 = diet; 1 = oral hypoglycemic agents; 2 = insulin. DBP = Diastolic blood pressure; CRP = C-reactive protein.