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. 2016 Jun 9;6:27525. doi: 10.1038/srep27525

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(a) Fluorescent image of four resected lymph nodes before (upper picture) and 15 minutes after (bottom picture) administration of gGlu-HMRG. (b,c) Fluorescent images 15 minutes after administration of gGlu-HMRG (left) and H&E staining (middle) of two metastatic lymph nodes. The small yellow circles on the left indicate the ROIs that showed the strongest increase in fluorescent intensity within 5 minutes. The small red boxes in the middle images correspond with the yellow circles on the left. Magnified H&E staining of the regions within the red boxes are shown on the right, and these were diagnosed as cancerous lesions by pathological examination. (d) Time-dependent increases in the fluorescent intensity of each lymph node after administration of gGlu-HMRG.