Table 2. Individual patient characteristics.
| No | Code | Group | Age/Sex | Ante-mortem assessment of brain disease/mental state | Cause of death | Braak Stage (Amyloid load) | PMD (h) | Brain Wt (g) |
|---|---|---|---|---|---|---|---|---|
| 1 | H155 | Control | 61/M | No brain disease or dementia | Ischemic heart disease | 0 (0) | 7.0 | 1258 |
| 2 | H121 | Control | 64/F | No brain disease or dementia | Pulmonary embolism | 0 (0) | 5.5 | 1260 |
| 3 | H132 | Control | 63/F | No brain disease or dementia | Ruptured aorta | 0 (0) | 12.0 | 1280 |
| 4 | H122 | Control | 72/F | No brain disease or dementia | Emphysema | 0 (0) | 9.0 | 1230 |
| 5 | H204 | Control | 66/M | No brain disease or dementia | Ischemic heart disease | 0 (0) | 9.0 | 1461 |
| 6 | H241 | Control | 76/F | No brain disease or dementia | Metastatic carcinoma | II (A3, B1, C1) | 12.0 | 1094 |
| 7 | H164 | Control | 73/M | No brain disease or dementia | Ischemic heart disease | 0 (0) | 13.0 | 1315 |
| 8 | H123 | Control | 78/M | No brain disease or dementia | Ruptured aortic aneurysm | 0 (0) | 7.5 | 1260 |
| 9 | H150 | Control | 78/M | No brain disease or dementia | Ruptured MI | 0 (0) | 12.0 | 1416 |
| 10 | AZ42 | AD | 60/M | Alzheimer’s dementia | Alzheimer’s disease | VI (3/3) | 7.0 | 1020 |
| 11 | AZ71 | AD | 62/F | Alzheimer’s dementia | Alzheimer’s disease | VI (3/3) | 6.0 | 831 |
| 12 | AZ48 | AD | 63/F | Alzheimer’s dementia | Bronchopneumonia | VI (2/3) | 7.0 | 1080 |
| 13 | AZ72 | AD | 70/F | Alzheimer’s dementia | Lung cancer | V (3/3) | 7.0 | 1044 |
| 14 | AZ90 | AD | 73/M | Alzheimer’s dementia | GI hemorrhage | IV (3/3) | 4.0 | 1287 |
| 15 | AZ96 | AD | 74/F | Alzheimer’s dementia | Metastatic cancer | V (3/3) | 8.5 | 1062 |
| 16 | AZ39 | AD | 74/M | Alzheimer’s dementia | Pseudomonas bacteremia | VI (2/3) | 12.0 | 1355 |
| 17 | AZ80 | AD | 77/M | Alzheimer’s dementia | Myocardial infarction | VI (3/3) | 4.5 | 1180 |
| 18 | AZ38 | AD | 80/M | Alzheimer’s dementia | Bronchopneumonia/ pulmonary oedema | V (3/3) | 5.5 | 1039 |
Abbreviations: GI, gastrointestinal; MI, myocardial infarction; PMD, post-mortem delay; wt, weight. Cause of death was determined by post-mortem examination, and brain pathology and Braak Stage were determined by specialist neuropathological examination. All AD cases had ‘Age-Related Plaque’ scores of “C”. Causes of death were the primary causes listed on the death certificate. Patient H241 had post-mortem signs consistent with AD and was therefore diagnosed with preclinical disease: the corresponding data have been retained in the main analysis presented in the manuscript, and removed from the control group for the secondary analysis. Control patient H241 (preclinical AD) was described as A3, B1, C1 using the ‘ABC’ criteria for AD neuropathologic change that incorporates histopathological assessments of Aβ deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C)2.