Table 3. Study of post-mortem human brain: relative fold-changes in glucose, sorbitol and fructose in seven brain regions from nine Alzheimer’s cases and nine controls.

Metabolite	Brain-region	Estimate	Lower Bound	Upper Bound	P-value	BH FDR Q-value
Glucose	Cerebellum	5.2	1.4	18.6	0.015	0.015
	Entorhinal cortex	7.4	2.4	23.2	0.0028	0.0041
	Cingulate gyrus	8.0	2.4	26.1	0.0023	0.0037
	Hippocampus	8.9	2.9	27.4	0.0016	0.0030
	Sensory cortex	9.2	3.0	28.8	0.0014	0.0029
	Motor cortex	11.8	3.7	37.7	0.0006	0.0019
	Middle temporal gyrus	16.4	5.2	51.2	0.0002	0.0019
Sorbitol	Cerebellum	3.7	1.6	8.6	0.0036	0.0044
	Entorhinal cortex	4.3	2.0	9.1	0.0006	0.0019
	Cingulate gyrus	3.1	1.5	6.5	0.0048	0.0053
	Hippocampus	4.1	1.9	8.5	0.0009	0.0021
	Sensory cortex	4.1	1.9	8.6	0.0009	0.0021
	Motor cortex	3.0	1.4	6.6	0.0090	0.0094
	Middle temporal gyrus	3.3	1.5	6.9	0.0039	0.0046
Fructose	Cerebellum	5.3	2.0	14.4	0.0018	0.0031
	Entorhinal cortex	5.7	2.4	13.5	0.0004	0.0019
	Cingulate gyrus	3.9	1.7	9.2	0.0030	0.0041
	Hippocampus	5.5	2.3	12.9	0.0005	0.0019
	Sensory cortex	5.4	2.4	12.4	0.0004	0.0019
	Motor cortex	4.2	1.7	10.2	0.0032	0.0041
	Middle temporal gyrus	5.7	2.6	12.9	0.0003	0.0019

Estimates and their lower and upper bounds were derived by Bayesian modelling. This table incorporates values from n = 9 patients with clinical diagnoses of AD and n = 9 matched asymptomatic controls. Abbreviation: ‘BH FDR Q-value’ is the Benjamini-Hochberg False- Discovery Rate-adjusted P-value.