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. 2016 Jun 9;6:27647. doi: 10.1038/srep27647

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Copyright © 2016, Macmillan Publishers Limited

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(a) Representative current traces showing the inhibition of different ASICs by PcTx1. ASICs were activated with pH 4.0 (pH 6.0 for homomeric ASIC1a) for 10 s and allowed to recover for 120 s in pH 6.95 (pH 7.4 for ASIC1a). 50 nM PcTx1 was applied in the conditioning solution before the second activation. (b) Comparison of the inhibition by PcTx1 of the different ASICs. The difference between ASIC1a-2a-1a and ASIC1a-2a-2a (p < 0.001) as well as the difference between ASIC1a-2a-1a and ASIC1a/2a (p < 0.001) were significant. There was no significant difference between ASIC1a/2a and ASIC1a-2a-2a. Maximal current amplitudes were 9.6 ± 1.9 μA (ASIC1a), 15.2 ± 1.7 μA (ASIC1a/2a), 12.9 ± 2.8 μA (ASIC1a-2a-1a), and 9.1 ± 1.4 μA (ASIC1a-2a-2a), respectively. Data are reported as mean ± SEM (n = 8–10).