Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 9;6:27647. doi: 10.1038/srep27647

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(a) Representative current trace showing the inhibition of ASICs by PcTx1 at conditioning pH 6.95. ASICs were activated with pH 6.0 for 15 s and allowed to recover for 60 s in pH 6.95. 50 nM PcTx1 was applied in the conditioning solution before the third activation. (b) Quantitative analysis of six measurements like the one shown in (a). Symbols represent six individual neurons, bars represent mean and SD, respectively. Conditioning pH 6.95 desensitized homomeric ASIC1a and heteromeric ASIC1a/2b. Co-application of PcTx1 revealed the PcTx1-sensitivity of the remaining ASIC1a/2a heteromers in these neurons.