Table 1. Pharmacokinetic parameters of PTX after intravenous injection of iRGD-NCs-PTX, PEG-NCs-PTX and NCs-PTX at a dose of 10 mg/kg in rats (n = 3).

Formulations	AUC0-∞(mg·h/L)	MRT (h)	k (h−1)	CL (L·h−1)
Taxol®	4.38 ± 3.57	1.78 ± 0.88	2.99 ± 2.88	1.68 ± 1.19
NCs-PTX	18.84 ± 7.07	15.17 ± 6.15	0.044 ± 0.023	0.12 ± 0.054
PEG-NCs-PTX	5.67 ± 0.60	3.03 ± 1.78	0.99 ± 0.69	0.19 ± 0.089
iRGD-NCs-PTX	25.61 ± 3.98	6.52 ± 1.23	0.098 ± 0.0093	0.08 ± 0.013

k: elimination rate constant.